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KMID : 0605720140200020119
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Journal of the Korean Society of Biological Therapies in Psychiatry
2014 Volume.20 No. 2 p.119 ~ p.126
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Preliminary Study of the Effects of Benzodiazepine and Sleep Deprivation on Psychomotor Function
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Byun Joon-Hyeong
Bae Kyung-Yeol
Jin You-Yang
Kang Hee-Ju
Lee Ju-Yeon
Kim Sung-Wan
Kim Jae-Min
Shin Il-Seon
Kim Seon-Young
Yoon Jin-Sang
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Abstract
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Objectives：The use of benzodiazepine and sleep deficiency both impair psychomotor function. Individuals with insufficient sleep often take benzodiazepine during the day for various reasons, such as anxiety. However, few studies have examined the extent to which the psychomotor effects of benzodiazepine interact with insufficient sleep. Therefore, this study examined the interaction of benzodiazepine and sleep deprivation on psychomotor function in healthy young males.
Methods：Four healthy males(age 23-26 years) participated in this study. Using a double-blind, placebo-controlled, crossover design, each subject was administered one of the following four conditions in a random order at 1-week intervals : 8 h in bed?placebo ; 8 h in bed?0.5 mg lorazepam ; 4 h in bed?placebo ; or 4 h in bed?0.5 mg lorazepam. Psychomotor functions were assessed at baseline and five times over 8.5 h after taking the study medications using the Critical Flicker Fusion Threshold, Choice Reaction Time, Compensatory Tracking Task, Digit Symbol Substitution Test, and Color-Word Stroop Tests.
Results：On the Color Stroop Test, there were significant differences among the conditions at 6.5(T4)(χ2=8.100, p= 0.044) and 8.5(T5)(χ2=8.100, p=0.044) h post-dose. In post hoc tests, 4 h in bed?0.5 mg lorazepam tended to cause more impairment than the other conditions.
Conclusion：There was some evidence that benzodiazepine-induced psychomotor impairment is potentiated by sleep deprivation. Future studies with larger sample sizes are required to validate this finding.
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KEYWORD
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Benzodiazepine, Sleep deprivation, Psychomotor function
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